Engineering DNA-Templated Nonribosomal Peptide Synthesis
نویسندگان
چکیده
منابع مشابه
Nonribosomal peptide synthesis and toxigenicity of cyanobacteria.
Nonribosomal peptide synthesis is achieved in prokaryotes and lower eukaryotes by the thiotemplate function of large, modular enzyme complexes known collectively as peptide synthetases. These and other multifunctional enzyme complexes, such as polyketide synthases, are of interest due to their use in unnatural-product or combinatorial biosynthesis (R. McDaniel, S. Ebert-Khosla, D. A. Hopwood, a...
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In fungi, nonribosomal peptide synthetases (NRP synthetases) are large multi-functional enzymes containing adenylation, thiolation (or peptidyl carrier protein, PCP) and condensation domains. These enzymes are often encoded within gene clusters. Multiple NRP synthetase ORFs have also been identified in fungi (14 in Aspergillus fumigatus). LeaA, a methyltransferase, is involved in secondary meta...
متن کاملReview Nonribosomal peptide synthesis in Aspergillus fumigatus and other fungi
In fungi, nonribosomal peptide synthetases (NRP synthetases) are large multi-functional enzymes containing adenylation, thiolation (or peptidyl carrier protein, PCP) and condensation domains. These enzymes are often encoded within gene clusters. Multiple NRP synthetase ORFs have also been identified in fungi (14 in Aspergillus fumigatus). LeaA, a methyltransferase, is involved in secondary meta...
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DNA-templated organic synthesis (DTS) enables new modes of controlling chemical reactivity and allows evolutionary principles to be applied to the discovery of synthetic small molecules, synthetic polymers, and new chemical reactions. The structures that can be accessed in a DNA-templated format thus far have been limited to those that can be generated in aqueous solvents. Here we report effici...
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It has been known for almost twenty years that nucleic acids may promote chemical reactions. Catalytic nucleic acids can be found in nature or evolved through in vitro selection processes.[1] Structural and functional investigations suggest that catalytically active nucleic acids act in a similar manner to enzymes: they promote chemical reactions through the precise spatial alignment of the rea...
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ژورنال
عنوان ژورنال: Cell Chemical Biology
سال: 2021
ISSN: 2451-9456
DOI: 10.1016/j.chembiol.2020.11.004